Elena Dreassi Selected Research

Pyrimidines

1/2023	Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme.
11/2022	Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment.
6/2019	A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor.
7/2018	Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-d]pyrimidines for Targeting Hepatocellular Carcinoma.
1/2017	Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.
1/2017	Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line.
2/2016	Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery.
1/2015	Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma.
4/2011	Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.
12/2010	2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

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Elena Dreassi Research Topics

Disease

13	Neoplasms (Cancer) 01/2024 - 01/2015
6	Glioblastoma (Glioblastoma Multiforme) 02/2024 - 05/2015
4	Neuroblastoma 03/2022 - 01/2015
2	Leukemia 11/2022 - 04/2011
2	Hypertension (High Blood Pressure) 08/2022 - 09/2015
2	Hepatocellular Carcinoma (Hepatoma) 11/2021 - 07/2018
2	Globoid Cell Leukodystrophy (Krabbe Disease) 11/2014 - 06/2013
2	Osteosarcoma (Osteogenic Sarcoma) 12/2010 - 09/2009
1	Lung Diseases (Lung Disease) 04/2023
1	COVID-19 11/2022
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/2022
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022
1	Coinfection 12/2021
1	Carcinoma (Carcinomatosis) 11/2021
1	Corneal Diseases (Corneal Disease) 01/2021
1	Keratoconus 01/2021
1	Cystic Fibrosis (Mucoviscidosis) 12/2019
1	Infections 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Metabolic Diseases (Metabolic Disease) 04/2016
1	Alkaptonuria 04/2016
1	Tyrosinemias (Tyrosinemia) 04/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 03/2016
1	Rhinitis 09/2015
1	Arthralgia (Joint Pain) 09/2015
1	Cough 09/2015
1	Fever (Fevers) 09/2015
1	Hypothyroidism 09/2015
1	Tauopathies 06/2015
1	Brain Neoplasms (Brain Tumor) 05/2015
1	Disease Progression 11/2014

Drug/Important Bio-Agent (IBA)

10	PyrimidinesIBA 01/2023 - 12/2010
6	pyrimidineIBA 03/2022 - 09/2009
4	ProdrugsIBA 02/2024 - 01/2017
3	Antineoplastic Agents (Antineoplastics)IBA 03/2022 - 01/2017
3	src-Family KinasesIBA 06/2019 - 09/2009
2	VaccinesIBA 05/2023 - 09/2015
2	EnzymesIBA 04/2023 - 09/2015
2	Therapeutic UsesIBA 01/2023 - 01/2015
2	Antiviral Agents (Antivirals)IBA 11/2022 - 12/2021
2	Phosphotransferases (Kinase)IBA 11/2022 - 06/2015
2	Fibrinolysin FDA Link 11/2021 - 07/2018
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 11/2014
2	Adenosine Triphosphate (ATP)IBA 06/2019 - 06/2015
2	Liposomes (Liposome)IBA 07/2018 - 02/2016
2	Tyrosine (L-Tyrosine)FDA Link 07/2018 - 04/2016
2	GalactosylceramidaseIBA 11/2014 - 06/2013
1	AntioxidantsIBA 01/2024
1	chitotriosidaseIBA 04/2023
1	ChitinasesIBA 04/2023
1	Tyrosine Kinase InhibitorsIBA 01/2023
1	Transcription Factors (Transcription Factor)IBA 01/2023
1	bcr-abl Fusion ProteinsIBA 11/2022
1	Cetuximab (Erbitux)FDA Link 09/2022
1	Antihypertensive Agents (Antihypertensives)IBA 08/2022
1	CSK Tyrosine-Protein KinaseIBA 03/2022
1	Gemcitabine FDA Link 01/2022
1	Nonesterified Fatty Acids (NEFA)IBA 01/2022
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2021
1	Peptide Hydrolases (Proteases)FDA Link 11/2021
1	CopperIBA 01/2021
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 12/2019
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 06/2019
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 06/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2018
1	Protein Isoforms (Isoforms)IBA 12/2017
1	3-nitrobenzoic acidIBA 12/2017
1	Carboxylic AcidsIBA 12/2017
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 12/2017
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2017
1	Human Serum Albumin FDA LinkGeneric 01/2017
1	Homogentisic AcidIBA 04/2016
1	HerbicidesIBA 04/2016
1	nitisinone (Orfadin)FDA Link 04/2016
1	DioxygenasesIBA 04/2016
1	Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)IBA 04/2016
1	Anti-Infective Agents (Microbicides)IBA 03/2016
1	AlbuminsIBA 02/2016
1	tetraphenylporphine sulfonate (TPPS)IBA 09/2015
1	EpitopesIBA 09/2015
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 09/2015
1	Protein Subunit VaccinesIBA 09/2015
1	Interleukin-2 (IL2)IBA 09/2015
1	Thymidylate SynthaseIBA 09/2015
1	Peptides (Polypeptides)IBA 09/2015
1	tau Proteins (tau Protein)IBA 06/2015
1	SI221 compoundIBA 05/2015
1	Fatty Acids (Saturated Fatty Acids)IBA 11/2014
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2010

Therapy/Procedure

3	Therapeutics 06/2019 - 12/2017
1	Precision Medicine 02/2024
1	Radiotherapy 05/2020
1	Highly Active Antiretroviral Therapy (HAART) 01/2018